FACILE SYNTHESIS OF 2-NITROALKANOLS BY TETRAMETHYLGUANIDINE (TMG)-CATALYZED ADDITION OF PRIMARY NITROALKANES TO ALDEHYDES AND ALICYCLIC KETONES

Authors
SIMONI D INVIDIATA FP MANFREDINI S FERRONI R LAMPRONTI I ROBERTI M POLLINI GP
Citation
D. Simoni et al., FACILE SYNTHESIS OF 2-NITROALKANOLS BY TETRAMETHYLGUANIDINE (TMG)-CATALYZED ADDITION OF PRIMARY NITROALKANES TO ALDEHYDES AND ALICYCLIC KETONES, Tetrahedron letters, 38(15), 1997, pp. 2749-2752
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
15
Year of publication
1997
Pages
2749 - 2752
Database
ISI
SICI code
0040-4039(1997)38:15<2749:FSO2BT>2.0.ZU;2-A
Abstract
Tetramethylguanidine-catalyzed addition of primary nitroalkanes to ald ehydes and alicyclic ketones constitutes a practical means to perform the nitro-aldol reaction (Henry reaction). The very mild conditions em ployed, together with the short reaction times, make the procedure tol erant of a range of functionalities and highly versatile for the synth esis of a variety of 2-nitroalkanols. (C) 1997 Elsevier Science Ltd.