Effects of somatostatin on proximal gastric motor function and visceral perception

Background: Somatostatin affects gastrointestinal motility and secretion an d visceral sensation, but little is known about its effects on the proximal stomach. Aim: To evaluate the effects of somatostatin on proximal gastric motor func tion and perception of symptoms. Methods: Six healthy subjects participated in two experiments performed in random order during continuous intravenous infusion of saline or somatostat in (250 mu g/h). Proximal gastric motor function was evaluated using a baro stat, We performed pressure and volume distensions and a barostat procedure (minimal distending pressure + 2 mmHg). Symptoms were evaluated at regular intervals using visual analogue scales (VAS). Results: Neither minimal distending pressure nor gastric fundal tone were s ignificantly different between somatostatin and saline. Pressure-volume cur ves during distensions were not influenced by somatostatin, However, phasic volume waves were significantly (P < 0.001) reduced by somatostatin, and s omatostatin significantly (P < 0.05) reduced symptom perception of fullness and abdominal pressure during stepwise distensions.