F. Nielloud et al., Formulation of insoluble drugs. Study of pharmaceutical suspensions by response surface methodology, ANALUSIS, 26(8), 1998, pp. 277-281
The preformulation of insoluble drugs, sulfadiazine and aluminium hydroxyde
, were studied in order to achieve a suspension with desirable requirements
. The objective of the formulator is to avoid the irreversible aggregation
called "caking", and to obtain a suspension with an airy, large volume sedi
ment easily redispersible and with suitable rheological properties. An expe
rimental design useful to determine optimal properties is a Central Composi
te Design. The surfactant, thickener and electrolyte at different proportio
ns are the 3 factors studied. This strategy allows to point on the main sig
nificant effect and to determine the concentrations of each product leading
to optimal properties of the suspensions.