The clinical diagnosis of pulmonary embolism (PE), even massive, remains di
fficult and perplexing. In our hospital, the percentage of exact clinical d
iagnoses has not significantly changed over recent years, with a false-nega
tive rate of 78%, and a false-positive rate of 2%. In approximately 20% of
cases, autopsy showed several emboli and pulmonary infarctions of various a
ges, indicating recurrent embolic episodes. The diseases most frequently as
sociated were cardiac diseases (51%) and tumours (24%). Pneumonia considera
bly decreases the probability of an exact diagnosis of PE; hospitalisation
in the Cardiology department or Intensive Care Unit increased the probabili
ty of this diagnosis. While the numerous diagnostic algorithms recently pro
posed have a limited value, the process integrating clinical and instrument
al data in order to establish a prospective clinical probability, should fa
cilitate identification of acute PE in live patients.