Phenprobamate (CAS 673-31-4) is a centrally acting skeletal-muscle relaxant
agent. There are only two studies in the literature about the pharmacokine
tics of phenoprobamate in man. The inconsistency between the results of the
se studies can be attributed partly to the different analytical methodologi
es used. A sensitive, specific and reproducible HPLC-assay, which may incre
ase the reliability of the pharmacokinetic studies of phenprobamate in plas
ma, has been developed recently.
The objective of this investigation was to assess the single-dose kinetics
of phenprobamate in human and to determine the pharmacokinetic parameters o
f clinical and regulatory concern. The plasma pharmacokinetics of phenproba
mate have been investigated following single oral administration at a dose
of 800 mg in eleven healthy volunteers.