Resolution of enantiomers of ibuprofen by liquid chromatography: A review

Ibuprofen is one of the most effective and widely used non-steroidal analge sic and anti-inflammatory agent. It is marketed as a racemic mixture though it is known that the pharmacological activity resides in the (S)-(+)-enant iomer only. Several direct/indirect liquid chromatographic methods involvin g a variety of chiral/achiral phases along with their possible role in reso lution, chiral and achiral agents used for derivatisation have been discuss ed with special reference to ibuprofen, and mentioning their application to the resolution of other 2-aryl-propionic acids/profens, (C) 1998 John Wile y & Sons, Ltd.