Angiogenesis in the hollow fiber tumor model influences drug delivery to tumor cells: Implications for anticancer drug screening programs

Citation
Rm. Phillips et al., Angiogenesis in the hollow fiber tumor model influences drug delivery to tumor cells: Implications for anticancer drug screening programs, CANCER RES, 58(23), 1998, pp. 5263-5266
Citations number
13
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER RESEARCH
ISSN journal
00085472 → ACNP
Volume
58
Issue
23
Year of publication
1998
Pages
5263 - 5266
Database
ISI
SICI code
0008-5472(199812)58:23<5263:AITHFT>2.0.ZU;2-I
Abstract
The National Cancer Institute uses the hollow fiber assay as part of its sc reening program for anticancer drug discovery. Angiogenesis to hollow fiber s implanted s.c. has not been reported, thereby raising concerns about the efficiency of drug delivery and its subsequent effects on chemosensitivity, By extending postimplantation times beyond the 6-day period presently used , extensive vascular networks develop, resulting in both increased delivery and chemosensitivity to doxorubicin. This study suggests that present prot ocols used to evaluate compounds may produce false negative results, and ad ditional studies to determine the predictive value of the assay are require d.