High-performance liquid chromatographic assay for perindopril in tablets

Authors
Gumieniczek, A Hopkala, H
Citation
A. Gumieniczek et H. Hopkala, High-performance liquid chromatographic assay for perindopril in tablets, CHEM ANAL, 43(6), 1998, pp. 951-954
Citations number
6
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
CHEMIA ANALITYCZNA
ISSN journal
00092223 → ACNP
Volume
43
Issue
6
Year of publication
1998
Pages
951 - 954
Database
ISI
SICI code
0009-2223(1998)43:6<951:HLCAFP>2.0.ZU;2-Z
Abstract
A new, simple and accurate high-performance liquid chromatography method is presented for measuring perindopril in tablets, using a reversed-phase tec hnique, UV detection at 211 nm and quinapril as an internal standard. Linea r detection response was obtained for the concentrations range from 0.1 to 0.5 mg ml(-1). The limit of detection was 50 mu g ml(-1). Perindopril was e xtracted from tablets with methanol. The percentage of recovery ranged from 95.0 to 102.75%.