Radically novel prostaglandins in animals and plants: the isoprostanes

Authors
Mueller, MJ
Citation
Mj. Mueller, Radically novel prostaglandins in animals and plants: the isoprostanes, CHEM BIOL, 5(12), 1998, pp. R323-R333
Citations number
90
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CHEMISTRY & BIOLOGY
ISSN journal
10745521 → ACNP
Volume
5
Issue
12
Year of publication
1998
Pages
R323 - R333
Database
ISI
SICI code
1074-5521(199812)5:12<R323:RNPIAA>2.0.ZU;2-A
Abstract
Animal prostaglandins and plant jasmonates are well-known enzymatically for med cyclopentanoic lipids that have regulatory functions and serve as induc ible mediators of host defense reactions. A novel group of prostaglandin-li ke compounds, the isoprostanes, generated in animals and plants by a nonenz ymatic, free radical-catalyzed process, are now suspected to be mediators o f oxidant injury in vivo.