Efficient method for pinacol coupling of aromatic and aliphatic ketones byusing titanium(II) chloride and zinc in the presence of pivalonitrile

Authors
Mukaiyama, T Kagayama, A Shiina, I
Citation
T. Mukaiyama et al., Efficient method for pinacol coupling of aromatic and aliphatic ketones byusing titanium(II) chloride and zinc in the presence of pivalonitrile, CHEM LETT, (11), 1998, pp. 1107-1108
Citations number
20
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
11
Year of publication
1998
Pages
1107 - 1108
Database
ISI
SICI code
0366-7022(199811):11<1107:EMFPCO>2.0.ZU;2-0
Abstract
The reductive coupling reaction of aromatic and aliphatic ketones including acyclic aliphatic ketones proceeded smoothly to give the corresponding pin acols in good to high yields below room temperature by the combined use of titanium(II) chloride and zinc in the presence of pivalonitrile. Meso-selec tive formation of the coupling products was observed in the cases with some acyclic aliphatic ketones.