Glomerular filtration rate determination in diabetic patients using iohexol clearance - comparison of single and multiple plasma sampling methods

Citation
Ta. Chowdhury et al., Glomerular filtration rate determination in diabetic patients using iohexol clearance - comparison of single and multiple plasma sampling methods, CLIN CHIM A, 277(2), 1998, pp. 153-158
Citations number
12
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
CLINICA CHIMICA ACTA
ISSN journal
00098981 → ACNP
Volume
277
Issue
2
Year of publication
1998
Pages
153 - 158
Database
ISI
SICI code
0009-8981(199810)277:2<153:GFRDID>2.0.ZU;2-N
Abstract
Use of iohexol clearance has been described as the gold standard for the me asurement of glomerular filtration rate (GFR). It is suggested that multipl e plasma sampling following iohexol injection is required to accurately det ermine GFR by area under plasma clearance curve. The aim of this study was to determine whether single plasma sampling 4 h after injection of iohexol could accurately determine GFR in diabetic patients with mild to moderate r enal failure, compared to multiple plasma sampling. A total of 120 GFR dete rminations in 36 patients with non-insulin dependent diabetic renal disease were done over 1 year. No acute deterioration was seen in renal function f ollowing injection of contrast in any patient. Strong correlation in GFR me asurement was observed between the multiple plasma sampling method and the single plasma sampling method (r(2) = 0.975). Single plasma sampling 4 h af ter bolus injection of iohexol is a safe and accurate method of determining GFR and change in GFR in diabetic subjects with mild to moderate renal imp airment. (C) 1998 Elsevier Science B.V. All rights reserved.