Serum concentration of calcium, 1,25 vitamin D and parathyroid hormone arenet correlated with coronary calcifications. An electron beam computed tomography study
Y. Arad et al., Serum concentration of calcium, 1,25 vitamin D and parathyroid hormone arenet correlated with coronary calcifications. An electron beam computed tomography study, CORON ART D, 9(8), 1998, pp. 513-518
Background The amount of coronary artery calcification, measured using elec
tron beam computed tomography, is correlated with the volume of coronary ar
tery atherosclerotic plaque, the severity of stenosis by angiography, and w
ith the likelihood of future cardiovascular events, The deposition of calci
um in atherosclerotic plaques may also be influenced by determinants of cal
cium metabolism, thus contributing to the variance of the relation between
coronary artery calcification and extent of atherosclerosis. Our objective
was to determine whether this variance could be explained by differences in
the parameters of calcium metabolism.
Design and methods We measured serum concentrations of calcium, 1,25(OH)(2)
vitamin D and parathyroid hormone (PTH) in 50 subjects undergoing angiogra
phy for clinical indications, and evaluated the correlations between these
concentrations and calcium deposition in the coronary arteries, and the rat
io of calcium deposition to extent of atherosclerosis using coronary angiog
raphy,
Results and conclusions Serum concentrations of calcium 1,25(OH)(2) vitamin
D and PTH were not correlated with coronary calcification or the ratio of
coronary calcification to the extent of coronary stenosis, We conclude that
, in subjects undergoing coronary angiography, the variance of the relation
ship between coronary atherosclerosis and coronary calcium is not a result
of differences in serum concentrations of calcium, 1,25(OH)(2) vitamin D or
PTH, Coronary Artery Dis 9:513-518 (C) 1998 Lippincott Williams & Wilkins.