Inhaled salbutamol decreases blood ammonia levels during exercise in normal subjects

Authors
Matthys, D Calders, P Pannier, JL
Citation
D. Matthys et al., Inhaled salbutamol decreases blood ammonia levels during exercise in normal subjects, EUR J A PHY, 79(1), 1998, pp. 110-113
Citations number
14
Categorie Soggetti
Physiology
Journal title
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY
ISSN journal
03015548 → ACNP
Volume
79
Issue
1
Year of publication
1998
Pages
110 - 113
Database
ISI
SICI code
0301-5548(199812)79:1<110:ISDBAL>2.0.ZU;2-M
Abstract
The present study examines the effect of salbutamol, a beta 2-adrenorecepto r agonist, on blood ammonia levels during an incremental cycle exercise tes t in healthy non-asthmatic subjects. Blood ammonia levels were lower after inhalation of 400 meg of salbutamol than after placebo during submaximal ex ercise: 33 +/- 2 mu mol.l(-1) vs 48 +/- 9 mu mol.l(-1) at 220 W and 39 +/- 2 mu mol.l(-1) vs 50 +/- 4 mu mol.l(-1) at 260 W. At peak exercise there we re no significant differences. The results suggest that beta 2-adrenorecept ors are involved in the regulation of blood ammonia during exercise.