An estimated 1 in 4 women in the United States will be raped in their
lifetimes. Approximately 75% of all rapes are date or acquaintance rap
es. Recently the illegal use of flunitrazepam (Rohypnol), a benzodiaze
pine, as a prelude to the assault has been reported. Flunitrazepam rea
dily dissolves, and once in solution, is colorless, odorless, and tast
eless. The predominant clinical manifestations are drowsiness, impaire
d motor skills, and anterograde amnesia. Due to the amnestic effects o
f flunitrazepam, historical clues of the rape event are difficult to o
btain. Patients with a complaint of sexual assault who appear intoxica
ted or have anterograde amnesia should be suspected of unknowingly ing
esting flunitrazepam. In addition to adhering to standard rape protoco
ls, a urine specimen should be analyzed for flunitrazepam metabolites
using gas chromatography/mass spectrometry. If the hospital, local, or
forensic laboratory is unable to analyze for flunitrazepam, Hoffmann-
La Roche Inc., the manufacturer of Rohypnol, should be contacted. Hoff
mann-La Roche has a mechanism for definitive testing for flunitrazepam
, at no cost, for health care providers, rape treatment centers, and l
aw enforcement agencies. A network of organizations is attempting to r
educe the abuse of flunitrazepam in association with date rape.