Iodine determination in biological materials - Options for sample preparation and final determination

This paper describes the development of various new acid sample decompositi on methods, as well as an extraction (leaching) method and compares them wi th the "Schoniger Combustion" technique. The methods have been developed as sample preparation techniques for iodine determination in biological mater ials, especially in solid samples. ICP-MS (inductively coupled plasma mass spectrometry) and a catalytic technique are employed and discussed fur the final determination of iodine concentrations. Accuracy and reliability of t he different analytical methods are shown in the examples of different CRMs (certified reference materials) available for iodine. The re suits of an i nterlaboratory comparison are specifically presented for the extraction (le aching) method.