Non-immune resistance to platelet concentration transfusions in patients with aplastic anemia and hemoblastoses

In the course of transfusion therapy of thrombocytopenic hemorrhagic syndro me, patients with blood diseases may develop alloimmune and non-immune resi stance to the transfused platelets. Low or absent therapeutic efficiency of transfusions of platelet concentrates may be due to such complicating fact ors as high fever, splenomegaly, coagulopathy, DIG-syndrome or their combin ations. The factors induce a low increase of platelet count 1 and 24 hours after the transfusion, abolish or diminish its therapeutic effect. Clinical findings are presented on 1280 cases of non-immune resistance which in lin e with alloimmunization remain a complex and unsolved problem of current tr ansfusiology.