Cytogenetics of uterine sarcomas: Presentation of eight new cases and review of the literature

Tissue from 14 uterine tumor samples from eight patients-four with endometr ial stromal sarcoma (ESS), two with leiomyosarcoma (ULMS), and two with mal ignant mixed mesodermal tumor (MMMT)-were investigated cytogenetically afte r short-term culturing, Clonal chromosome aberrations were found in 12 tumo rs. One ESS showed a recombination between 7p14 and 17q12, a rearrangement characterizing a subset of ESSs, In our series, chromosomes 1, 6, 7, and 16 were involved in structural aberrations most frequently (four cases each), Net loss of 6q material was found in four cases and bands 11q13, 16q13, an d 22q13 were each rearranged in four cases. Among 43 uterine sarcomas, incl uding 12 MMTs, now available for evaluation, some differences in breakpoint distribution among different tumor types were found. Rearrangements of ban ds 1p32, 3p24, and 10q22 were found exclusively in ULMS, whereas aberration s of bands 6p21, 7p21, and 17q12 were found predominantly in ESS, (C) 1998 Academic Press.