In vitro modulation of bcl-2 protein expression, drug-induced apoptosis and cytotoxicity by interleukin-10 in chronic lymphocytic leukemia

Authors
Morabito, F Filangeri, M Sculli, G Oliva, B
Citation
F. Morabito et al., In vitro modulation of bcl-2 protein expression, drug-induced apoptosis and cytotoxicity by interleukin-10 in chronic lymphocytic leukemia, HAEMATOLOG, 83(11), 1998, pp. 1046-1048
Citations number
7
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
83
Issue
11
Year of publication
1998
Pages
1046 - 1048
Database
ISI
SICI code
0390-6078(199811)83:11<1046:IVMOBP>2.0.ZU;2-Y
Abstract
Interleukin-10 failed to modify either the percentage of bcl-2(+) cells or the number of bcl-2 molecules, or to reduce 2-chlorodeoxyadenosine- and flu darabine-induced apoptosis. The cytokine at 0.1 ng/mL Induced an increase o f cell survival both in the absence or in the presence of 2-chlorodeoxyaden osine, while no difference was appreciated with fludarabine.