Synthesis and activity as a glycosidase inhibitor of 2,8-dihydroxyindolizidines

Authors
Na, HS Choi, J Yu, JH Shin, KJ Yoo, KH Kim, DJ Park, SW
Citation
Hs. Na et al., Synthesis and activity as a glycosidase inhibitor of 2,8-dihydroxyindolizidines, HETEROCYCLE, 48(11), 1998, pp. 2365-2378
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
48
Issue
11
Year of publication
1998
Pages
2365 - 2378
Database
ISI
SICI code
0385-5414(19981101)48:11<2365:SAAAAG>2.0.ZU;2-L
Abstract
The synthesis and enzyme assay of 2,8-dihydroxyindolizidines (5) were descr ibed. Four diastereomers of these were prepared from trans-4-hydroxy-L-prol ine (6) which is commercially available amino acid. Among synthetic compoun ds 5a(1) and 5b(2) showed medium potent inhibition to alpha-amyloglycosidas e, while 5a(2) displayed medium activity to alpha-glucosidase.