Ed. Murphey et al., EFFECTS OF CONTINUOUS VENOVENOUS HEMOFILTRATION ON CARDIOPULMONARY FUNCTION IN A PORCINE MODEL OF ENDOTOXIN-INDUCED SHOCK, American journal of veterinary research, 58(4), 1997, pp. 408-413
Objective-To determine whether continuous venovenous hemofiltration, p
roposed to remove inflammatory mediators from circulation, would resol
ve cardiopulmonary derangements in a model of established endotoxic sh
ock. Animals-16 clinically normal pigs. Procedure-Endotoxin was infuse
d, IV, into anesthetized pigs for a total of 50 minutes. Thirty minute
s after termination of the infusion period, extracorporeal circulation
was initiated through a 50-kd diafilter, or past the filter without u
ltrafiltrate formation. Cardiac and respiratory variables were monitor
ed for a period of 4 hours. Results-Infusion of lipopolysaccharide res
ulted in a severe hypodynamic circulatory slate, with significant decr
eases in mean arterial pressure and cardiac output concurrent with a s
ignificant increase in pulmonary arterial pressure. Hemofiltration was
not associated with any correction of lipopolysaccharide-induced card
iopulmonary derangements. Conclusions-Continuous venovenous hemofiltra
tion, as used in this acute experiment, did not improve cardiopulmonar
y dysfunction during endotoxic shock. Clinical Relevance-Continuous ve
novenous hemofiltration needs further investigation before it can be r
ecommended as a clinically effective treatment.