Case report - One normal child and a chromosomally balanced/normal twin after intracytoplasmic sperm injection in a male with a de-novo t(Y;16) translocation

A balanced translocation t(Y;16)(q11.21;q24) is described in a male with se vere oligoasthenoteratozoospermia (OAT), Before having a chromosome investi gation, the patient and his partner had undergone intracytoplasmic sperm in jection (ICSI) treatment resulting in the birth of a healthy 46,XX child. A fter detection of the t(Y;16) translocation, the couple opted for further I CSI treatment, although they were extensively counselled on the risk of hav ing chromosomally unbalanced offspring. This treatment resulted in a twin p regnancy, one with a 46,XX karyotype and the other a 46,X,t(Y;16) (q11,21;q 24) karyotype, the same as the father. After an uncomplicated pregnancy two healthy children were born. We conclude that patients with a Y/autosome tr anslocation as a cause of OAT can have chromosomally normal children after ICSI treatment.