Obstetric outcome after prenatal diagnosis in pregnancies obtained after intracytoplasmic sperm injection

In this study we compared the pregnancy outcome of 576 pregnancies after pr enatal diagnosis with that of 540 pregnancies without prenatal diagnosis in our microinjection programme. Amniocentesis was suggested for singleton pr egnancies (n = 465) and chorionic villus sampling (CVS) was proposed for tw in pregnancies (n = 111 pregnancies, 222 fetuses). A total of 365 patients with singleton pregnancies and 175 patients with twin pregnancies who did n ot undergo prenatal diagnosis were selected as controls. Compared with the controls, the odds ratios in the amniocentesis group for preterm delivery, low birthweight, very low birthweight and fetal loss were 0.97 [95% confide nce interval (CT): 0.60-1.57], 1.27 (95% CI: 0.78-2.06), 1.57 (95% CI: 0.53 -4.66) and 0.86 (95% CI: 0.32-2.37) respectively. Compared with the control s, the odds ratios in the CVS group for preterm delivery, low birthweight, very low birthweight and fetal loss were 0.89 (95% CI: 0.61-1.30), 1.03 (95 % CI: 0.74-1.45), 0.79 (95% CI: 0.41-1.53) and 0.47 (95% CI: 0.17-1.30) res pectively. We concluded that, in this series of intracytoplasmic sperm inje ction (ICSI) pregnancies, prenatal testing did not increase the preterm-del ivery, the low-birthweight, or the very low-birthweight rates as compared w ith those of the controls. In the prenatal diagnosis group, the fetal loss rate was comparable to that of the control group. Larger prospective contro lled studies are needed in order to inform patients reliably about the risk s and the advantages of prenatal testing in ICSI pregnancies.