STUDIES ON MENADIONE AS AN INHIBITOR OF THE CDC25 PHOSPHATASE

It has been recently reported that some of the CDC25 genes have been i mplicated in the progression of cell cycle and might display oncogenic properties in mammalian cells. Therefore, the inhibition of this phos phatase may hold promise in the treatment of human cancer. In this stu dy, we demonstrated that cdc25 phosphatase can be inactivated by menad ione and that the loss of enzymatic activity was due to the modificati on of the active site. (C) 1997 Academic Press.