Correlation of cecal microflora of HLA-B27 transgenic rats with inflammatory bowel disease

Authors
Onderdonk, AB Richardson, JA Hammer, RE Taurog, JD
Citation
Ab. Onderdonk et al., Correlation of cecal microflora of HLA-B27 transgenic rats with inflammatory bowel disease, INFEC IMMUN, 66(12), 1998, pp. 6022-6023
Citations number
12
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
66
Issue
12
Year of publication
1998
Pages
6022 - 6023
Database
ISI
SICI code
0019-9567(199812)66:12<6022:COCMOH>2.0.ZU;2-N
Abstract
Transgenic rats with a high level of expression of the human major histocom patibility complex class I molecule HLA-B27 develop chronic inflammatory bo wel disease (IBD) and arthritis. Assessment of the cecal microflora showed a rise in numbers of Escherichia coil and Enterococcus spp., corresponding to the presence and severity of IBD in these rats.