Toothbrushes date back nearly 1000 years, although the forerunners of today
's brushes were developed in the 1930s. Ideally toothbrushes should be desi
gned to promote optimum plaque removal with minimum adverse effects to the
hard and soft tissues. Unlike the development of other oral hygiene product
s, notably toothpaste and mouthrinses, there appears to have been no debate
of how best to evaluate the safety and efficacy of toothbrushes except per
haps in respect of filament stiffness. Even here there has been little cons
ideration of the interplay of toothbrushes with toothpaste for safety and e
fficacy, a factor complicated by the multi-factorial aetiology of tooth wea
r and gingival recession. This review considers present and possible future
laboratory and clinical methodologies whereby toothbrushes could be assess
ed for safety and efficacy. To date, for the most part, studies have concen
trated on brush comparisons. This approach cannot be criticised since studi
es, in the main, have conformed with scientific guidelines. However, it has
achieved little except to emphasise that the major variable to safety and
more particularly efficacy is the brusher and not the brush. A proposal is
pat forward that minimum standards for toothbrush safety and efficacy based
on laboratory and clinical experiments be considered.