Honokiol induces apoptosis in human lymphoid leukemia Molt 4B cells

Authors
Hibasami, H Achiwa, Y Katsuzaki, H Imai, K Yoshioka, K Nakanishi, K Ishii, Y Hasegawa, M Komiya, T
Citation
H. Hibasami et al., Honokiol induces apoptosis in human lymphoid leukemia Molt 4B cells, INT J MOL M, 2(6), 1998, pp. 671-673
Citations number
17
Categorie Soggetti
Medical Research General Topics
Journal title
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN journal
11073756 → ACNP
Volume
2
Issue
6
Year of publication
1998
Pages
671 - 673
Database
ISI
SICI code
1107-3756(199812)2:6<671:HIAIHL>2.0.ZU;2-2
Abstract
The exposure of human lymphoid leukemia Molt 4B cells to honokiol led to bo th growth inhibition and the induction of apoptosis. Morphological change s howing apoptotic bodies was observed in the cells treated with honokiol. Th e fragmentation by honokiol of DNA to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and tim e-dependent. These findings suggest that growth inhibition by honokiol of M olt 4B cells results from the induction of apoptosis in the cells.