New medicinal treatment for severe gingivostomatitis

We formulated de novo a poraprezinc-sodium alginate suspension (P-AG) as a specific treatment for severe gingivostomatitis and administered it to 15 p atients who had developed such inflammation while on chemotherapy. Very hig h utility of P-AG was demonstrated and the response was classified as excel lent in 10 patients and good in 5 patients. The mechanism of the beneficial effect of P-AG in treatment of severe gingivostomatitis accompanied by hem orrhagic erosion and ulcers is considered to involve the mucosal protective effect, free radical scavenging activity and tissue repair promoting actio n of poraprezinc together with the hemostatic action of sodium alginate.