Many animals use their vomeronasal organs to gain direct and specific conta
ct with chemical cues released by congeners and in biological fluids. These
cues provide information about the physiological status of the emitter and
facilitate or regulate social interactions such as sexual relationships. T
he present review gives a short description of the discovery of the vomeron
asal organ and the pivotal findings of Jacobson. The distribution of the or
gan and its anatomy in some vertebrates are described. The mechanisms for s
timulus entry and egress are discussed, and the findings that led to the ap
preciation of the vomeronasal organ in mammals as a main chemosensory organ
for pheromones mediating reproductive status and inducing sexual behaviour
are reported. The anatomical, biochemical and functional properties of the
receptor neurones are described.