CD43 is associated with tyrosine kinase activity in human neutrophils

CD43 appears to be involved in signal transduction, however, the mechanism of this function is unknown. Protein kinase activity was detected in neutro phils associated with CD43. Most of the protein kinase activity associated with these antigens was tyrosine kinase activity. The src family kinases ly n and hck were found to account for much of the associated tyrosine kinase activity. The data suggest that associated tyrosine kinase activity may pla y a role in signal transduction via CD43 to regulate other cell functions.