Starfish saponins. 55. Isolation, structure elucidation, and biological activity of the steroid oligoglycosides from an antarctic starfish of the family Asteriidae

This paper reports an analysis of the chemical constituents from an Antarct ic starfish of the family Asteriidae. Different steroid glycoside types are represented among its constituents, including the five hexaglycoside stero idal sulfates ("asterosaponins") asteriidosides A-E (1-5), differing in the ir oligosaccharide chain, and the two nonsulfated diglycosides asteriidosid e F (6) and G (7), in which 6 is the 26-methyl analogue of 7. Also present are the two sulfated diglycosides asteriidoside H (8) and I (9) and one sul fated monoglycoside asteriidoside L (10). Eight of the compounds were teste d against human nonsmall-cell lung carcinoma cells (NSCLC-L16) and found to be moderately cytotoxic.