Cytotoxic and leishmanicidal aminoglycosteroids and aminosteroids from Holarrhena curtisii

Authors
Kam, TS Sim, KM Koyano, T Toyoshima, M Hayashi, M Komiyama, K
Citation
Ts. Kam et al., Cytotoxic and leishmanicidal aminoglycosteroids and aminosteroids from Holarrhena curtisii, J NAT PROD, 61(11), 1998, pp. 1332-1336
Citations number
38
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
61
Issue
11
Year of publication
1998
Pages
1332 - 1336
Database
ISI
SICI code
0163-3864(199811)61:11<1332:CALAAA>2.0.ZU;2-R
Abstract
The EtOH extract of the leaves of Holarrhena curtisii yielded five new ster oidal alkaloids: 17-epi-holacurtine (3), 17-epi-N-demethylholacurtine (4), holacurtinol (5), 3 alpha-amino-14 beta-hydroxypregnan-20-one (7), and 15 a lpha-hydroxyholamine (8), in addition to the known compounds, holacurtine ( 1), N-demethylholacurtine (2), and holamine (6). All eight compounds showed significant cytotoxic and leishmanicidal activities.