New macrodiolide antibiotics, 11-O-monomethyl- and 11,11 '-O-dimethylelaiophylins, from Streptomyces sp. HKI-0113 and HKI-0114

Authors
Ritzau, M Heinze, S Fleck, WF Dahse, HM Grafe, U
Citation
M. Ritzau et al., New macrodiolide antibiotics, 11-O-monomethyl- and 11,11 '-O-dimethylelaiophylins, from Streptomyces sp. HKI-0113 and HKI-0114, J NAT PROD, 61(11), 1998, pp. 1337-1339
Citations number
11
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
61
Issue
11
Year of publication
1998
Pages
1337 - 1339
Database
ISI
SICI code
0163-3864(199811)61:11<1337:NMA1A1>2.0.ZU;2-3
Abstract
Elaiophylin (1) and two new methyl derivatives, 11-O-monomethylelaiophylin (2) and 11,11'-O-dimethylelaiophylin (3), were isolated from the mycelium c ake of Streptomyces strains HKI-0113 and HKI-0114. The structures of 2 and 3 were determined by mass spectrometric and NMR investigations. Compounds 2 and 3 display antimicrobial and moderate cytotoxic activities.