Quanolirones I and II, two new human cytomegalovirus protease inhibitors produced by Streptomyces sp. WC76535

Authors
Qian-Cutrone, J Kolb, JM McBrien, K Huang, S Gustavson, D Lowe, SE Manly, SP
Citation
J. Qian-cutrone et al., Quanolirones I and II, two new human cytomegalovirus protease inhibitors produced by Streptomyces sp. WC76535, J NAT PROD, 61(11), 1998, pp. 1379-1382
Citations number
19
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
61
Issue
11
Year of publication
1998
Pages
1379 - 1382
Database
ISI
SICI code
0163-3864(199811)61:11<1379:QIAITN>2.0.ZU;2-A
Abstract
Two new naphthacenequinone glycosides, quanolirones I (1) and II (2) were i solated, together with the known compound galtamycin from the fermentation broth of Streptomyces sp. WC76535. The structures 1 and 2 were established by analysis of their spectroscopic data and by comparison of their data to those of galtamycin. Compounds 1, 2, and galtamycin showed inhibitory activ ity against HCMV protease with IC50 values of 14, 35, and 52 mu M, respecti vely.