A novel antiprotozoal aminosteroid from Saracha punctata

Authors
Moretti, C Sauvain, M Lavaud, C Massiot, G Bravo, JA Munoz, V
Citation
C. Moretti et al., A novel antiprotozoal aminosteroid from Saracha punctata, J NAT PROD, 61(11), 1998, pp. 1390-1393
Citations number
21
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
61
Issue
11
Year of publication
1998
Pages
1390 - 1393
Database
ISI
SICI code
0163-3864(199811)61:11<1390:ANAAFS>2.0.ZU;2-0
Abstract
A new aminosteroid, 3 beta-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-beta-D-glucopyranos yl-eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promast igotes (100% at 25 mu M) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 mu M) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.