Isolation and structure elucidation of new PKC alpha inhibitors from Pinusflexilis

Authors
Lee, KK Bahler, BD Hofmann, GA Mattern, MR Johnson, RK Kingston, DGI
Citation
Kk. Lee et al., Isolation and structure elucidation of new PKC alpha inhibitors from Pinusflexilis, J NAT PROD, 61(11), 1998, pp. 1407-1409
Citations number
26
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
61
Issue
11
Year of publication
1998
Pages
1407 - 1409
Database
ISI
SICI code
0163-3864(199811)61:11<1407:IASEON>2.0.ZU;2-Q
Abstract
Bioassay-guided fractionation of the CH2Cl2-MeOH extract of Pinus flexilis using an assay for protein kinase C (PKC) inhibitory activity led to the is olation of the two new bioactive diarylheptanoids (3R)-1,7-bis(3,4-dihydrox yphenyl)-3-(beta-D-glucopyranosyl)heptan-3-ol (1) and its aglycon (3R)-1,7- bis(3,4-dihydroxyphenyl)heptan-3-ol (2), together with the three known bioa ctive compounds, hirsutenone (3), oregonin (4), and hirsutanonol (5). The I C50 values of compounds 1-5 in the PKC assay were 1.4, 1.6, 1.4, 8.6, and 4 .6 mu g/mL, respectively.