Complement activation and CD59 expression in the motor facial nucleus following intracranial transection of the facial nerve in the adult rat

Intracranial transection of the facial nerve has been shown to cause a mass ive neuronal cell death in the motor facial nucleus. Complement activation has been proposed to contribute to neuronal degeneration following axotomy. Using immunocytochemistry and in situ hybridization we show in the present study that there is complement activation in the facial nucleus after intr acranial facial nerve transection as well as increase of the complement reg ulators CD59 and clusterin. We propose a neuroprotective role for the compl ement regulators CD59 and clusterin against homologous attack of complement to facial motor neurons. (C) 1998 Elsevier Science B.V. All rights reserve d.