Mobius' syndrome: Features and etiology

Purpose: To review the clinical features and possible aetiology of all case s of Mabius' syndrome presented at the Royal Alexandra Hospital for Childre n in Sydney, Australia, from 1963 through 1995. Methods: All charts of patients suffering from Mobius' syndrome were review ed, and each patient was thoroughly assessed by a geneticist and a pediatri c ophthalmologist. Results: Patterns of systemic and ocular clinical features became evident. Of 23 patients in the series, 10 (43%) had a history significant events in utero. Conclusions: All patients suffering from Mobius' syndrome require thorough assessment by a multidisciplinary team including a geneticist or pediatrici an and a pediatric ophthalmologist. Significant vascular events of pregnanc y may explain some cases of fetal vascular disruption to the brainstem.