Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment

Objective: We compared the activity and tolerance profile of a 0.05% retina ldehyde cream with a 0.05% retinoic acid cream and the retinaldehyde vehicl e in patients with photodamaged skin of the face. Methods: A silicone replica of the left crow's feet area was taken at basel ine and at weeks 18 and 44. Skin replicas were then analyzed by means of an optical profilometry technique. Standard wrinkle and roughness features we re then calculated and statistically analyzed. The tolerance profile of the test products was also clinically evaluated during the entire study. Results: A total of 125 patients (40 in the retinoic acid group, 40 in the retinaldehyde group, and 45 in the vehicle group) were studied. At week 18, a significant reduction of the wrinkle and roughness features was observed with both retinaldehyde and retinoic acid. At week 44, a less pronounced r eduction was demonstrated in bath active groups. No statistically significa nt changes were observed with the retinaldehyde vehicle at any assessment p oint. A total of 135 patients constituted the safety population. Retinaldeh yde was well tolerated during the entire study. In contrast, retinoic acid caused more local irritation, and affected compliance of the patients. Conclusion: Retinaldehyde was efficacious and well tolerated in patients wi th photodamage.