In 1990, prostaglandin (PG) F-2-like compounds were discovered to be p
roduced in abundance in vivo by a free radical mechanism independent o
f the cyclooxygenase enzyme. Because these compounds are isomeric to c
yclooxygenase-derived PGF(2 alpha), they were termed F-2-isoprostanes
(F-2-IsoP's). Subsequently, it was also demonstrated that PGD(2)-like
compounds (D-2-IsoP's) and PGE(2)-like compounds (E(2)-IsoP's) are als
o produced in vivo as products of this pathway. Four different regiois
omers of each of these classes of IsoP's are formed, each of which can
be comprised of eight racemic diastereomers. Thus, 64 different F-2-I
soP's, E(2)-IsoP's, and D-2-IsoP's can be formed. Interest in these mo
lecules stems not only from the fact that quantification of IsoP's can
provide a valuable index of free radical-induced lipid peroxidation i
n vivo but also from the fact that it has bean shown that these compou
nds are capable of exerting potent biological activity. Because of thi
s potential for exerting biological activity, the chemical syntheses o
f various IsoP compounds for biological testing has been initiated. As
a result, a need for a systematic nomenclature for these compounds ha
s evolved. A facile nomenclature that will allow rational differentiat
ion and designation of each of the isomeric structures comprising the
family of IsoP's is presented. (C) 1997 by Elsevier Science Inc.