THE EFFECTS OF CHEMOTHERAPY ON THE LONG-TERM SURVIVORS OF MALIGNANCY

It is estimated that by the year 2000 one in a thousand 20-year-olds w ill be a survivor of childhood cancer. Increasingly, chemotherapy alon e is being used because of concerns about the long-term effects of rad iotherapy. However, chemotherapy may also have long-term effects parti cularly on growth and body composition, cardiac function and fertility . Other important late effects include renal and lung toxicity, hearin g impairment, neuropsychological sequalae and secondary leukaemias.