In vivo differential diagnosis of prostate cancer and benign prostatic hyperplasia: Localized proton magnetic resonance spectroscopy using external-body surface coil

Localized proton-stimulated echo acquisition mode (STEAM) spectroscopy was performed in seven patients with benign prostatic hyperplasia (BPH), six pa tients with prostate cancer, and seven healthy volunteers to determine whet her citrate levels detected using a saddle-type external-body surface coil (two loops of 13 cm x 17 cm) could reliably discriminate BPH from prostatic cancer. Relative area ratios of citrate level to choline plus creatine or citrate to lipid signal were compared with postoperative pathologic histolo gy findings. The metabolic signals were well detectable as much as the line width of water resonance was ranging from 5 to 9 hz, Average SNRs of citra te in BPH and prostate cancer were 11.4 and 1.9, respectively. The major fi nding was consistently lower citrate levels in prostate cancer compared wit h BPH and normal prostate central gland, This was significantly (p < 0.01) reflected by lower mean citrate/[creatine + choline] peak area ratio and ci trate/lipid peak area ratio observed for region of cancer (0.446 +/- 0.063, 0.097 +/- 0.030) compared with BPH (1.458 +/- 0.107, 0.786 +/- 0.162) and normal central gland (1.418 +/- 0.129, 0.175 +/- 0.011), respectively. Thes e studies demonstrate the potential of citrate spectrum detected by an exte rnal-body surface coil as an in vivo marker for discriminating prostate can cer from BPH. (C) 1998 Elsevier Science Inc.