Comparative activity of cefotaxime and ceftriaxone on 203 strains of Streptococcus pneumoniae

The evolution of antimicrobial resistance of Streptococcus pneumoniae requi res the determination of the MICs to antibiotics, particularly beta-lactams . The third-generation cephalosporins are the empirical drugs of choice for pneumococcal infections, essentially meningitis, in areas of the world whe re penicillin-resistant pneumococci are prevalent. The aim of this study wa s to compare the MIC of cefotaxime and ceftriaxone obtained by the referenc e agar dilution method. The results showed a complete equivalence of the tw o molecules against S. pneumoniae.