Transplantation of fetal brain tissue into the site of intracerebral hemorrhage in rats

The purpose of this study was to evaluate whether transplantation of fetal forebrain tissue into the hematoma site of rats with intrastriatal hemorrha ge could improve the final neurological outcome. Nine to twelve days after collagenase-induced intracerebral hemorrhage, day 14 fetal forebrain fragme nts were transplanted into hematoma site. Quantitative measures of behavior al function were repeatedly evaluated until the rats were killed 10 weeks a fter grafting. Histology was used to assess the survival of the grafts and overall brain morphology. Surviving grafts were located in the residual cav ity at the hematoma site. However, comparison of rats with live transplants to control rats with no transplant, sham transplant, or dead tissue transp lant revealed no statistically significant differences in any of the motor tests. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.