Synthesis and biological evaluation of 1,2,5-oxadiazole N-oxide derivatives as hypoxia-selective cytotoxins

Authors
Monge, A de Cerain, AL Ezpeleta, O Cerecetto, H Dias, E Di Maio, R Gonzalez, M Onetto, S Seoane, G Suescun, L Mariezcurrena, R
Citation
A. Monge et al., Synthesis and biological evaluation of 1,2,5-oxadiazole N-oxide derivatives as hypoxia-selective cytotoxins, PHARMAZIE, 53(11), 1998, pp. 758-764
Citations number
32
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
53
Issue
11
Year of publication
1998
Pages
758 - 764
Database
ISI
SICI code
0031-7144(199811)53:11<758:SABEO1>2.0.ZU;2-E
Abstract
Synthesis and biological evaluation of new 1,2,5-oxadiazole N-oxide derivat ives with potential cytotoxic effects are described. From the series of com pounds tested, compounds 2 and 6 proved to be very active, although non-sel ective.