INVOLVEMENT OF THE CHROMOSOMAL REGION 11Q13 IN RENAL ONCOCYTOMA - CASE-REPORT AND LITERATURE-REVIEW

Renal oncocytomas comprise a cytogenetically heterogeneous group of tu mors consisting potentially of cytogenetic distinguishable subgroups. Review of the literature revealed loss of chromosome 1 and Y as a poss ible anomaly for at least one subset of oncocytomas. The frequent find ing of rearrangements involving chromosome 11 band q13 characterizes a nother subset of oncocytomas. We report the cytogenetic and pathologic al features of a renal oncocytoma diagnosed in a 72-year-old woman and found a t(9;11)(p23;q13) as a consistent abnormality. This supports t he idea that translocations involving 11q13 define a further subset of oncocytoma. (C) Elsevier Science Inc., 1997.