Citation
T. Orth et al., Analysis of epitope spreading over an eleven-year period in a patient withsystemic lupus erythematosus, SC J RHEUM, 27(6), 1998, pp. 461-464
Citations number
11
Categorie Soggetti
Rheumatology,"da verificare
Journal title
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
ISSN journal
03009742
→ ACNP
Volume
27
Issue
6
Year of publication
1998
Pages
461 - 464
Database
ISI
SICI code
0300-9742(1998)27:6<461:AOESOA>2.0.ZU;2-4
Abstract
During a period of more than eleven years serum samples of a patient with S
ystemic Lupus Erythematosus were collected and analyzed for anti-nuclear au
toantibodies. High titer of anti-La/SS - B were detectable in all serum sam
ples. The La/SS - B epitopes remained constant. Besides anti-La/SS - B anti
bodies all serum samples contained traces of anti-Ro/SS - A including anti-
Ro52 and anti-Ro60 antibodies. During disease hares anti-Ro/SS - A antibodi
es were upregulated and anti-dsDNA antibodies appeared, thus supporting the
concept of an antigen driven intermolecular epitope spreading to Ro/SS-A a
nd dsDNA.