INFLUENCE ON DNA DOUBLE HELIX STABILITY O F LIGANDS WHICH UNDERGO TEMPERATURE CONFORMATIONAL TRANSITIONS

The influence of ligands, which undergo conformational transition, on DNA molecular melting is considered theoretically. Equations for compu tation of melting curves of DNA included in such complexes are obtaine d, which are used for studies of DNA double helix stability and of the binding to helical and coil regions influence on ligand conformationa l transitions. Calculated melting curves and experimental data for DNA -RNAase complex are compared.