KCNQ2 and KCNQ3 potassium channel subunits: Molecular correlates of the M-channel

The M-current regulates the subthreshold electrical excitability of many ne urons, determining their firing properties and responsiveness to synaptic i nput. To date, however, the genes that encode subunits of this important ch annel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 pot assium channels were determined. It is concluded that both these subunits c ontribute to the native M-current.