EFFECT OF SYNTHETIC POLYCATION QUARTERNAR Y AMMONIUM SALT POLYMETACRYLOIL LUPININE ON ION PERMEABILITY OF ERYTHROCYTES MEMBRANES

It is shown that synthetic polycation quarternary ammonium salt polyme tacryloil lupinine (poly-MACL) effects on passive ion permeability of erythrocytes membranes. The amplitude of Cl-/OH- exchange decreased in the buffer with SDS-polycation complex and simultaneously with pH ele vation K+ exflux increased. On the contrary, in presence of heparin co effect of poly-MACL and SDS vanished. Thus, synthetic polycation in th e complex with longchain anion (SDS) injure the membranes and effect d epends on lipophilic-hydrophilic balance of polycation-SDS complex.