THE EFFECTS OF FE2+ IONS ON HEMOLYSIS IND UCED BY PRODUCTS OF PSORALEN PHOTOOXIDATION

Authors
ZHURAVEL NN BELICHENKO IV KYAGOVA AA LYSENKO EP KHALILOV EM POTAPENKO AY
Citation
Nn. Zhuravel et al., THE EFFECTS OF FE2+ IONS ON HEMOLYSIS IND UCED BY PRODUCTS OF PSORALEN PHOTOOXIDATION, Biofizika, 42(1), 1997, pp. 182-186
Citations number
12
Categorie Soggetti
Biophysics
Journal title
Biofizika → ACNP
ISSN journal
00063029
Volume
42
Issue
1
Year of publication
1997
Pages
182 - 186
Database
ISI
SICI code
0006-3029(1997)42:1<182:TEOFIO>2.0.ZU;2-Q
Abstract
The effects of Fe2+ ions on haemolysis induced by previously photooxid ized psoralen (POP-haemolysis) were investigated. It was shown that PO P-haemolysis was strongly activated by Fe2+ ions when ferrous ions wer e added to erythrocytes just after addition of POP. If POP was preincu bated with Fe2+ before mixing with erythrocytes, then POP completely l ost its ability to induce haemolysis. These data indicate the peroxidi c nature of POP products responsible for haemolysis.